If you have HWiNFO configure to Auto Start with Windows you might try to add a startup delay for its task in Task Scheduler.
If that won't help, I will need to see the HWiNFO Debug File.
HWiNFO® v8.27-5735 Beta available.
Changes:
Extended number of temperatures monitored (for CPUs with up-to 256 cores).
Added OSD independent window without title bar.
Added workaround for thermal throttling stuck sticky on Arrow Lake-H.
Looks like the problem is that the SMU stops responding to commands after a while (something could be stuck there).
Try to upgrade the BIOS (yours is from 9/2024), it might fix the problem.
Have you maybe associated the same hotkey with some other program or action?
You should still be able to go into OSD settings and turn the OSD off manually.
Do you at least get the welcome screen of HWiNFO? If yes, you can go into Settings and "Reset Preferences".
If not, run "regedit", navigate into "HKEY_CURRENT_USER\Software\HWiNFO64\OSD" and delete the entire key.
Beta builds can be downloaded from the main download page - grey button.
Switching to the window without title will lock the position, switching back will unlock it.
HWiNFO supports this but there are some systems which have locked access to DIMMs (using proprietary mechanisms) where we cannot access the SPD, PMIC or TS.