There is no performance loss of the system as a whole. Just more like ... It's something like the ASUS EC where it was recommended to disable it to increase the performance of HWINFO (faster polling speed). Just trying an extreme example like 100ms poll rate. If I disable every sensor except the "CPU [#0]: AMD Ryzen Threadripper 1950X" group, or disable every sensor except the "GPU [#0]: NVIDIA GeForce GTX 1080 Ti: " group, or have all groups enabled, it's about the same poll speed (250-300ms). It seems like doing any polling of sensors at all adds about 150-200ms of time per poll interval. Maybe this is just an effect of the threadripper platform?