This happens when I play a full screen or windowed borderless game on one monitor, with HWiNFO64 Sensors window running in "Always On Top" mode on a second monitor. It's as if HWiNFO is fighting with the game to be on top, crashing Windows Explorer.
This cannot be a bug in HWiNFO, but in the operating system. Looks like Microsoft still didn't catch some bugs in Windows 11.
Always On Top is a simple hint for operating system that handles this behavior. Moreover, no action performed by an application should cause a crash in a system process including explorer.exe.