Running HWiNFO in Debug Mode will not fix it, but produce a file which I need for analysis. Make sure you run the Debug Mode and capture the situation when it's not working (Stand by - Resume). Please search for the HWiNFO64.DBG file and send it to me.
Also a question - after resume when your profile doesn't work and you open the Fan Control window in HWiNFO, do you see there the original settings (Auto mode), or the settings you have set (in Manual mode) ?