This machines needs Hyper-V, which it has been running before the mainboard change as well, it is what this machines does, running a lot of Development VMs. So hyper-V is the breaking point, i can't disable that. I tried again Sensors only, interestingly the UI got stuck at Corsair Link. But that seems to be a side effect only. Deinstalled the Nvidia Drivers, and still the same, so that was not the rootcause too.